Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex

Kevin C. Ess, Christine A. Kamp, Benjamin P. Tu, David H. Gutmann

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Children with tuberous sclerosis complex (TSC) harbor developmental brain abnormalities (cortical tubers) and low-grade tumors (subependymal giant cell astrocytomas [SEGAs]). Using gene expression profiling to identify neuroglial differentiation markers in Tsc1 conditional knockout mice, the authors demonstrate that giant cells of SEGAs aberrantly express similar neuroglial differentiation markers as do cortical tubers. These results suggest that both tubers and SEGAs result from related defects in progenitor cell differentiation during brain development.

Original languageEnglish
Pages (from-to)1446-1449
Number of pages4
JournalNeurology
Volume64
Issue number8
DOIs
StatePublished - Apr 26 2005

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