TY - JOUR
T1 - Developmental Delay and School Performance Among Retinoblastoma Survivors
T2 - Development/school morbidity among retinoblastoma survivors
AU - Reynolds, Margaret
AU - Lueder, Gregg
AU - Gordon, Mae
AU - Hayashi, Robert J.
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/9
Y1 - 2021/9
N2 - Purpose: The purpose of this study was to describe the academic performance of childhood retinoblastoma (RB) survivors. Design: Retrospective cohort study. Methods: Retrospective chart review of children followed in a survivorship clinic. Results: A total of 73 patients with RB (median age at diagnosis: 9.97 months; range: 0.29-65.1) were followed for a median of 6.4 years (0.2-1.76). A total of 48 patients (65.8%) had unilateral RB; 43 patients (63.0%) received systemic chemotherapy; and 57 patients (78.1%) underwent enucleation. At last follow-up, 5 children (6.8%) had bilateral visual acuity (VA) <20/70. Seventeen subjects (23.3%) reported school difficulties, and 10 subjects (13.7%) had an individualized education program (IEP). Multivariate analysis revealed that a history of receiving chemotherapy” Multivariate analysis revealed that a history of receiving chemotherapy was associated with self-reported school difficulties (odds ratio [CI]: 5.44; 95% confidence interval [CI]: 1.36-21.69; P =.016), and undergoing an IEP (OR: 11.47; 95% CI: 1.34-98.16; P =.03). The degree of visual impairment and history of enucleation did not influence the risk of self-reported school difficulties or the implementation of an IEP. Among unilateral RB patients, chemotherapy was an independent risk factor for self-reported school difficulties (OR: 12.8; 95% CI: 1.45-113; P =.009) and implementation of an IEP (OR: 15.2; 95% CI: 0.78-292; P =.02). Conclusions: Academic difficulties in childhood RB survivors are associated with chemotherapy treatment, a risk factor independent of VA.
AB - Purpose: The purpose of this study was to describe the academic performance of childhood retinoblastoma (RB) survivors. Design: Retrospective cohort study. Methods: Retrospective chart review of children followed in a survivorship clinic. Results: A total of 73 patients with RB (median age at diagnosis: 9.97 months; range: 0.29-65.1) were followed for a median of 6.4 years (0.2-1.76). A total of 48 patients (65.8%) had unilateral RB; 43 patients (63.0%) received systemic chemotherapy; and 57 patients (78.1%) underwent enucleation. At last follow-up, 5 children (6.8%) had bilateral visual acuity (VA) <20/70. Seventeen subjects (23.3%) reported school difficulties, and 10 subjects (13.7%) had an individualized education program (IEP). Multivariate analysis revealed that a history of receiving chemotherapy” Multivariate analysis revealed that a history of receiving chemotherapy was associated with self-reported school difficulties (odds ratio [CI]: 5.44; 95% confidence interval [CI]: 1.36-21.69; P =.016), and undergoing an IEP (OR: 11.47; 95% CI: 1.34-98.16; P =.03). The degree of visual impairment and history of enucleation did not influence the risk of self-reported school difficulties or the implementation of an IEP. Among unilateral RB patients, chemotherapy was an independent risk factor for self-reported school difficulties (OR: 12.8; 95% CI: 1.45-113; P =.009) and implementation of an IEP (OR: 15.2; 95% CI: 0.78-292; P =.02). Conclusions: Academic difficulties in childhood RB survivors are associated with chemotherapy treatment, a risk factor independent of VA.
UR - http://www.scopus.com/inward/record.url?scp=85108538838&partnerID=8YFLogxK
U2 - 10.1016/j.ajo.2021.04.025
DO - 10.1016/j.ajo.2021.04.025
M3 - Article
C2 - 33965417
AN - SCOPUS:85108538838
SN - 0002-9394
VL - 229
SP - 266
EP - 273
JO - American journal of ophthalmology
JF - American journal of ophthalmology
ER -