Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system

Ioanna Kotsopoulou; Arpita K. Vyas; Melinda J. Cory; Christina S. Chan; Jawahar Jagarapu; Shamaila Gill; Manjula Mudduluru; Dimitrios Angelis

doi:10.1038/s41372-022-01559-3

Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system

Ioanna Kotsopoulou, Arpita K. Vyas, Melinda J. Cory, Christina S. Chan, Jawahar Jagarapu, Shamaila Gill, Manjula Mudduluru, Dimitrios Angelis

Division of Endocrinology and Diabetes

Research output: Contribution to journal › Review article › peer-review

Abstract

Thyroid hormones play an important role in the development and function of the cardiac myocyte. Dysregulation of the thyroid hormone milieu affects the fetal cardiac cells via complex molecular mechanisms, either by altering gene expression or directly by affecting post-translational processes. This review offers a comprehensive summary of the effects of thyroid hormones on the developing cardiovascular system and its adaptation. Furthermore, we will highlight the gaps in knowledge and provide suggestions for future research.

Original language	English
Pages (from-to)	1576-1586
Number of pages	11
Journal	Journal of Perinatology
Volume	42
Issue number	12
DOIs	https://doi.org/10.1038/s41372-022-01559-3
State	Published - Dec 2022

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abstract = "Thyroid hormones play an important role in the development and function of the cardiac myocyte. Dysregulation of the thyroid hormone milieu affects the fetal cardiac cells via complex molecular mechanisms, either by altering gene expression or directly by affecting post-translational processes. This review offers a comprehensive summary of the effects of thyroid hormones on the developing cardiovascular system and its adaptation. Furthermore, we will highlight the gaps in knowledge and provide suggestions for future research.",

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AU - Chan, Christina S.

AU - Jagarapu, Jawahar

AU - Gill, Shamaila

AU - Mudduluru, Manjula

AU - Angelis, Dimitrios

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AB - Thyroid hormones play an important role in the development and function of the cardiac myocyte. Dysregulation of the thyroid hormone milieu affects the fetal cardiac cells via complex molecular mechanisms, either by altering gene expression or directly by affecting post-translational processes. This review offers a comprehensive summary of the effects of thyroid hormones on the developing cardiovascular system and its adaptation. Furthermore, we will highlight the gaps in knowledge and provide suggestions for future research.

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Developmental changes of the fetal and neonatal thyroid gland and functional consequences on the cardiovascular system

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