Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices

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Abstract

The effects of 100 μM d,l-2-amino-3-phosphonopropionate (AP3), 100 μM d,l-2-amino-4-phosphonobutyric acid (AP4), and 500 μM (R,S)-α-methyl-4-carboxyphenylglycine (MCPG), inhibitors of phosphoinositide (PI) turnover mediated by metabotropic glutamate receptors (mGluRs), on the induction of long-term potentiation (LTP) were examined in the CA1 region of hippocampal slices prepared from 15, 30 and 60 day old rats. In 15 or 30 day old rats, AP3 and MCPG applied for 5 min immediately after tetanization inhibited LTP. AP4 was less effective. All inhibitors were ineffective against LTP in 60 day old rats. These data support the hypothesis that the role of metabotropic glutamate receptors in LTP induction is influenced by development.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalNeuroscience Letters
Volume176
Issue number1
DOIs
StatePublished - Jul 18 1994

Keywords

  • (RS)-α-Methyl-4-carboxyphenylglycine
  • 2-Amino-3-phosphonopropionate
  • 2-Amino-4-phosphonobutyrate
  • Development
  • Hippocampus
  • Long-term potentiation
  • Metabotropic glutamate receptor
  • Phosphoinositide hydrolysis

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