TY - JOUR
T1 - Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices
AU - Izumi, Yukitoshi
AU - Zorumski, Charles F.
N1 - Funding Information:
This work was supported in part by the Diabetes Research and Training Center, NIMH Research Scientist Development Award MH00964, Grants MH45493 and AG05681, and a fellowship from the Bantly Foundation. The authors thank Drs. John W. Olney, and David B. Clifford for helpful advice and suggestions.
PY - 1994/7/18
Y1 - 1994/7/18
N2 - The effects of 100 μM d,l-2-amino-3-phosphonopropionate (AP3), 100 μM d,l-2-amino-4-phosphonobutyric acid (AP4), and 500 μM (R,S)-α-methyl-4-carboxyphenylglycine (MCPG), inhibitors of phosphoinositide (PI) turnover mediated by metabotropic glutamate receptors (mGluRs), on the induction of long-term potentiation (LTP) were examined in the CA1 region of hippocampal slices prepared from 15, 30 and 60 day old rats. In 15 or 30 day old rats, AP3 and MCPG applied for 5 min immediately after tetanization inhibited LTP. AP4 was less effective. All inhibitors were ineffective against LTP in 60 day old rats. These data support the hypothesis that the role of metabotropic glutamate receptors in LTP induction is influenced by development.
AB - The effects of 100 μM d,l-2-amino-3-phosphonopropionate (AP3), 100 μM d,l-2-amino-4-phosphonobutyric acid (AP4), and 500 μM (R,S)-α-methyl-4-carboxyphenylglycine (MCPG), inhibitors of phosphoinositide (PI) turnover mediated by metabotropic glutamate receptors (mGluRs), on the induction of long-term potentiation (LTP) were examined in the CA1 region of hippocampal slices prepared from 15, 30 and 60 day old rats. In 15 or 30 day old rats, AP3 and MCPG applied for 5 min immediately after tetanization inhibited LTP. AP4 was less effective. All inhibitors were ineffective against LTP in 60 day old rats. These data support the hypothesis that the role of metabotropic glutamate receptors in LTP induction is influenced by development.
KW - (RS)-α-Methyl-4-carboxyphenylglycine
KW - 2-Amino-3-phosphonopropionate
KW - 2-Amino-4-phosphonobutyrate
KW - Development
KW - Hippocampus
KW - Long-term potentiation
KW - Metabotropic glutamate receptor
KW - Phosphoinositide hydrolysis
UR - http://www.scopus.com/inward/record.url?scp=0027998505&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)90878-8
DO - 10.1016/0304-3940(94)90878-8
M3 - Article
C2 - 7970244
AN - SCOPUS:0027998505
VL - 176
SP - 89
EP - 92
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -