TY - JOUR
T1 - Developmental biology of glomerular basement membrane components
AU - Miner, Jeffrey H.
PY - 1998
Y1 - 1998
N2 - The main components of basement membranes are collagen IV, laminin, entactin/nidogen, and proteoglycans. In the past few years, new basement membrane components have been discovered, including new collagen IV α chains, new laminin α, β, and γ chains, and new proteoglycans. Most of these are expressed in the kidney, a virtual treasure chest of molecularly and functionally distinct basement membranes. One well characterized renal basement membrane is the glomerular basement membrane, the primary filtration barrier of the kidney. Immunohistochemical studies have shown not only that the glomerular basement membrane is molecularly distinct from other renal basement membranes, but also that as it develops, there is a complex series of defined transitions in the basement membrane components that are deposited there. This review summarizes these transitions and discusses their relevance in our understanding of the pathogenesis of renal disease.
AB - The main components of basement membranes are collagen IV, laminin, entactin/nidogen, and proteoglycans. In the past few years, new basement membrane components have been discovered, including new collagen IV α chains, new laminin α, β, and γ chains, and new proteoglycans. Most of these are expressed in the kidney, a virtual treasure chest of molecularly and functionally distinct basement membranes. One well characterized renal basement membrane is the glomerular basement membrane, the primary filtration barrier of the kidney. Immunohistochemical studies have shown not only that the glomerular basement membrane is molecularly distinct from other renal basement membranes, but also that as it develops, there is a complex series of defined transitions in the basement membrane components that are deposited there. This review summarizes these transitions and discusses their relevance in our understanding of the pathogenesis of renal disease.
UR - http://www.scopus.com/inward/record.url?scp=0031963693&partnerID=8YFLogxK
U2 - 10.1097/00041552-199801000-00003
DO - 10.1097/00041552-199801000-00003
M3 - Review article
C2 - 9442357
AN - SCOPUS:0031963693
VL - 7
SP - 13
EP - 19
JO - Current Opinion in Nephrology and Hypertension
JF - Current Opinion in Nephrology and Hypertension
SN - 1062-4821
IS - 1
ER -