Developmental and Transmittable Origins of Obesity-Associated Health Disorders

Arin K. Oestreich, Kelle H. Moley

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


The current global obesity pandemic is clearly linked to both the increasing prevalence of, and preference for, foods high in calories, specifically fat and sucrose, and declining levels of daily physical activity. A less commonly discussed possible explanation is that risk of obesity begins in utero as a result of developmental plasticity during early life. This idea fits into the broader Developmental Origins of Health and Diseases (DOHAD) hypothesis, which holds that stressful in utero exposure manifests as disease in adulthood. In this review, we highlight several studies that have revealed the role of epigenetics in multigenerational transmission of developmentally programmed obesity and associated cardiometabolic disease.

Original languageEnglish
Pages (from-to)399-407
Number of pages9
JournalTrends in Genetics
Issue number6
StatePublished - Jun 2017


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