TY - JOUR
T1 - Development of vestibular behaviors in zebrafish
AU - Bagnall, Martha W.
AU - Schoppik, David
N1 - Funding Information:
M.W.B. is supported by NIH R00DC012536 , R56DC016413 , a Pew Scholar Award , McKnight Foundation Scholar Award , and Alfred P. Sloan Fellowship . D.S. is supported by National Institute on Deafness and Communication Disorders of the National Institutes of Health under award numbers R00DC012775 , R56DC016316 , and a Whitehead Fellowship. The authors wish to thank David Ehrlich for helpful comments on the manuscript.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/12
Y1 - 2018/12
N2 - Most animals orient their bodies with respect to gravity to facilitate locomotion and perception. The neural circuits responsible for these orienting movements have long served as a model to address fundamental questions in systems neuroscience. Though postural control is vital, we know little about development of either balance reflexes or the neural circuitry that produces them. Recent work in a genetically and optically accessible vertebrate, the larval zebrafish, has begun to reveal the mechanisms by which such vestibular behaviors and circuits come to function. Here we highlight recent work that leverages the particular advantages of the larval zebrafish to illuminate mechanisms of postural development, the role of sensation for balance circuit development, and the organization of developing vestibular circuits. Further, we frame open questions regarding the developmental mechanisms for functional circuit assembly and maturation where studying the zebrafish vestibular system is likely to open new frontiers.
AB - Most animals orient their bodies with respect to gravity to facilitate locomotion and perception. The neural circuits responsible for these orienting movements have long served as a model to address fundamental questions in systems neuroscience. Though postural control is vital, we know little about development of either balance reflexes or the neural circuitry that produces them. Recent work in a genetically and optically accessible vertebrate, the larval zebrafish, has begun to reveal the mechanisms by which such vestibular behaviors and circuits come to function. Here we highlight recent work that leverages the particular advantages of the larval zebrafish to illuminate mechanisms of postural development, the role of sensation for balance circuit development, and the organization of developing vestibular circuits. Further, we frame open questions regarding the developmental mechanisms for functional circuit assembly and maturation where studying the zebrafish vestibular system is likely to open new frontiers.
UR - http://www.scopus.com/inward/record.url?scp=85048936769&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2018.06.004
DO - 10.1016/j.conb.2018.06.004
M3 - Review article
C2 - 29957408
AN - SCOPUS:85048936769
SN - 0959-4388
VL - 53
SP - 83
EP - 89
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -