Development of ventricular expansion and increased pulsatile CSF flow in a rat model

S. Rashid, M. E. Wagshul, M. Yu, H. Benveniste, J. Li, J. P. McAllister

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Adult rats were injected with kaolin in the basal cistern to impede cerebrospinal fluid flow and induce communicating hydrocephalus. Development and progress of CH was monitored using magnetic resonance imaging (MRI) for a period of over 30 days. TrueFISP images were used to measure volume of the cerebral aqueduct and the lateral, third and fourth ventricles as well as hydrodynamic resistance of the aqueduct. Retrospectively gated phase contrast gradient echo images were used to measure stroke volume of CSF in the aqueduct. Based on ventricular volumes, animals could be divided into 3 groups where Groups 2 & 3 developed mild and severe hydrocephalus respectively, while Group 1 did not. Ventricular volumes and stroke volumes of Group 3 increased over time, as expected, while in Group 2, ventricular volume increased but stroke volume increased and then decreased, a phenomenon that has not been reported before. Hydrodynamic resistance of aqueductal flow was found to correlate negatively with stroke volume for Groups 2 and 3, although at different levels.

Original languageEnglish
Title of host publication33rd Annual Northeast Bioengineering Conference - Engineering Innovations in Life Sciences and Healthcare, NEBC
PublisherInstitute of Electrical and Electronics Engineers Inc.
Number of pages2
ISBN (Print)1424410339, 9781424410330
StatePublished - 2007
Event33rd Annual Northeast Bioengineering Conference, NEBC - Stony Brook, NY, United States
Duration: Mar 10 2007Mar 11 2007

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)1071-121X


Conference33rd Annual Northeast Bioengineering Conference, NEBC
Country/TerritoryUnited States
CityStony Brook, NY


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