TY - JOUR
T1 - Development of Ultra-High Dose-Rate (FLASH) Particle Therapy
AU - Kim, Michele M.
AU - Darafsheh, Arash
AU - Schuemann, Jan
AU - Dokic, Ivana
AU - Lundh, Olle
AU - Zhao, Tianyu
AU - Ramos-Mendez, Jose
AU - Dong, Lei
AU - Petersson, Kristoffer
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Research efforts in FLASH radiotherapy (FLASH-RT) have increased at an accelerated pace recently. FLASH-RT involves ultra-high dose rates and has been shown to reduce toxicity to normal tissue while maintaining tumor response in preclinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to date with proton, electron, and heavy-ion FLASH-RT, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental setup, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH-RT are discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH-RT.
AB - Research efforts in FLASH radiotherapy (FLASH-RT) have increased at an accelerated pace recently. FLASH-RT involves ultra-high dose rates and has been shown to reduce toxicity to normal tissue while maintaining tumor response in preclinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to date with proton, electron, and heavy-ion FLASH-RT, with particular emphasis on the physical aspects of each study and the advantages and disadvantages of each modality. Beam delivery parameters, experimental setup, and the dosimetry tools used are described for each FLASH modality. In addition, modeling efforts and treatment planning for FLASH-RT are discussed along with potential drawbacks when translated into the clinical setting. The final section concludes with further questions that have yet to be answered before safe clinical implementation of FLASH-RT.
KW - Electron radiation
KW - FLASH effect modeling
KW - FLASH radiotherapy (FLASH-RT)
KW - heavy-ion radiation
KW - proton radiation
UR - http://www.scopus.com/inward/record.url?scp=85109421741&partnerID=8YFLogxK
U2 - 10.1109/TRPMS.2021.3091406
DO - 10.1109/TRPMS.2021.3091406
M3 - Article
AN - SCOPUS:85109421741
SN - 2469-7311
VL - 6
SP - 252
EP - 262
JO - IEEE Transactions on Radiation and Plasma Medical Sciences
JF - IEEE Transactions on Radiation and Plasma Medical Sciences
IS - 3
ER -