Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages

Chyi Song Hsieh, Steven E. Macatonia, Catherine S. Tripp, Stanley F. Wolf, Anne O'Garra, Kenneth M. Murphy

Research output: Contribution to journalArticlepeer-review

2738 Scopus citations

Abstract

Development of the appropriate CD4+ T helper (TH) subset during an immune response is important for disease resolution. With the use of naïve, ovalbumin-specific αβ T cell receptor transgenic T cells, it was found that heat-killed Listeria monocytogenes induced T H1 development in vitro through macrophage production of interleukin-12 (IL-12). Moreover, inhibition of macrophage production of IL-12 may explain the ability of IL-10 to suppress TH1 development. Murine immune responses to L. monocytogenes in vivo are of the appropriate T H1 phenotype. Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate TH phenotype.

Original languageEnglish
Pages (from-to)547-549
Number of pages3
JournalScience
Volume260
Issue number5107
DOIs
StatePublished - Jan 1 1993

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