Development of thyroid disease during therapy of chronic viral hepatitis with interferon alfa

Mauricio Lisker-Melman, Adrian M. Di Bisceglie, Stephen J. Usala, Bruce Weintraub, Linda M. Murray, Jay H. Hoofnagle

Research output: Contribution to journalArticlepeer-review

226 Scopus citations

Abstract

Six of 237 (2.5%) patients with chronic viral hepatitis who were treated with recombinant interferon alfa developed thyroid disease while on treatment. Three patients developed hyperthyroidism, two of whom developed detectable levels of thyroid-stimulating immunoglobulin; three patients developed hypothyroidism in association with high titers of antithyroglobulin and/or antimicrosomal antibodies. The thyroid disease did not remit when interferon therapy was stopped, and all six patients required definitive therapy for the thyroid disease. These findings suggest that a small proportion of patients treated with interferon alfa develop autoimmune reactions and can develop autoimmune thyroid disease.

Original languageEnglish
Pages (from-to)2155-2160
Number of pages6
JournalGastroenterology
Volume102
Issue number6
DOIs
StatePublished - Jun 1992

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