TY - JOUR
T1 - Development of the rat superior cervical ganglion
T2 - Initial stages of synapse formation
AU - Rubin, E.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1985
Y1 - 1985
N2 - Synapse formation in the rat superior cervical ganglion has been investigated electrophysiologically and at the ultrastructural level. Preganglionic axons first enter the superior cervical ganglion between days 12 and 13 of gestation (E12 to E13), and on E13 a postganglionic response can be evoked by preganglionic stimulation. The susceptibility of this response to fatigue and to blocking agents indicates that it is mediated by cholinergic synapses. On E14, the overall strength of ganglionic innervation arising from different spinal segments already varies in a pattern resembling that found in maturity. However, the distribution of synapses on individual target cells gradually changes in the prenatal period. Transmission begins prior to the elaboration of ganglion cell dendrites; therefore, the first contacts to form are largely axosomatic. As dendrites appear (beginning on E14), ultrastructural evidence shows that synaptogenesis becomes focused upon these processes. The significance of these findings is discussed in relation to possible mechanisms of the formation of appropriate synaptic connections.
AB - Synapse formation in the rat superior cervical ganglion has been investigated electrophysiologically and at the ultrastructural level. Preganglionic axons first enter the superior cervical ganglion between days 12 and 13 of gestation (E12 to E13), and on E13 a postganglionic response can be evoked by preganglionic stimulation. The susceptibility of this response to fatigue and to blocking agents indicates that it is mediated by cholinergic synapses. On E14, the overall strength of ganglionic innervation arising from different spinal segments already varies in a pattern resembling that found in maturity. However, the distribution of synapses on individual target cells gradually changes in the prenatal period. Transmission begins prior to the elaboration of ganglion cell dendrites; therefore, the first contacts to form are largely axosomatic. As dendrites appear (beginning on E14), ultrastructural evidence shows that synaptogenesis becomes focused upon these processes. The significance of these findings is discussed in relation to possible mechanisms of the formation of appropriate synaptic connections.
UR - http://www.scopus.com/inward/record.url?scp=0021950678&partnerID=8YFLogxK
U2 - 10.1523/jneurosci.05-03-00697.1985
DO - 10.1523/jneurosci.05-03-00697.1985
M3 - Article
C2 - 2983046
AN - SCOPUS:0021950678
VL - 5
SP - 697
EP - 704
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 3
ER -