Development of the neuromuscular junction: Genetic analysis in mice

Joshua R. Sanes, Elizabeth D. Apel, Robert W. Burgess, Ronald B. Emerson, Guoping Feng, Medha Gautam, David Glass, R. Mark Grady, Eric Krejci, Jeff W. Lichtman, Jonathan T. Lu, Jean Massoulié, Jeffrey H. Miner, Lisa M. Moscoso, Quyen Nguyen, Mia Nichol, Peter G. Noakes, Bruce L. Patton, Young Jin Son, George D. YancopoulosHeather Zhou

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Formation of the skeletal neuromuscular junction is a multi-step process that requires communication between the nerve and muscle. Studies in many laboratories have led to identification of factors that seem likely to mediate these interactions. 'Knock-out' mice have now been generated with mutations in several genes that encode candidate transsynaptic messengers and components of their effector mechanisms. Using these mice, it is possible to test hypotheses about the control of synaptogenesis. Here, we review our studies on neuromuscular development in mutant mice lacking agrin αCGRP, rapsyn, MuSK, dystrophin, dystrobrevin, utrophin, laminin ≱, laminin β2, collagen 3/4 (IV), the acetylcholine receptor ε subunit, the collagenous tail of acetylcholinesterase, fibroblast growth factor-5, the neural cell adhesion molecule, and tenascin-C.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalJournal of Physiology Paris
Issue number3-4
StatePublished - 1998


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