The female reproductive tract (FRT), which includes the oviduct, uterus, cervix and vagina, is critical for mammalian reproduction. Recent research using knockout mice has contributed substantially to our understanding of the molecular mechanisms governing FRT development. Aside from satisfying our curiosities about the origin of life, these studies have provided us with a better understanding of FRT disorders and ways to improve female fertility. Here we review genes that are involved in various stages of sexual duct formation and development in mammals. In addition, the effect of exogenous estrogen such as DES on FRT development is also discussed.

Original languageEnglish
Pages (from-to)677-683
Number of pages7
JournalJournal of Biochemistry
Issue number6
StatePublished - Jun 2005


  • DES
  • Müllerian duct
  • Uterine adenogenesis
  • Uterus
  • Wollfian duct


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