TY - JOUR
T1 - Development of the endochondral skeleton
AU - Long, Fanxin
AU - Ornitz, David M.
PY - 2013/1
Y1 - 2013/1
N2 - Much of the mammalian skeleton is composed of bones that originate fromcartilage templates through endochondral ossification. Elucidating the mechanisms that control endochondral bone development is critical for understanding human skeletal diseases, injury response, and aging. Mouse genetic studies in the past 15 years have provided unprecedented insights about molecules regulating chondrocyte formation, chondrocyte maturation, and osteoblast differentiation, all key processes of endochondral bone development. These include the roles of the secreted proteins IHH, PTHrP, BMPs, WNTs, and FGFs, their receptors, and transcription factors such as SOX9, RUNX2, and OSX, in regulating chondrocyte and osteoblast biology. This review aims to integrate the known functions of extracellular signals and transcription factors that regulate development of the endochondral skeleton.
AB - Much of the mammalian skeleton is composed of bones that originate fromcartilage templates through endochondral ossification. Elucidating the mechanisms that control endochondral bone development is critical for understanding human skeletal diseases, injury response, and aging. Mouse genetic studies in the past 15 years have provided unprecedented insights about molecules regulating chondrocyte formation, chondrocyte maturation, and osteoblast differentiation, all key processes of endochondral bone development. These include the roles of the secreted proteins IHH, PTHrP, BMPs, WNTs, and FGFs, their receptors, and transcription factors such as SOX9, RUNX2, and OSX, in regulating chondrocyte and osteoblast biology. This review aims to integrate the known functions of extracellular signals and transcription factors that regulate development of the endochondral skeleton.
UR - http://www.scopus.com/inward/record.url?scp=84872030260&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a008334
DO - 10.1101/cshperspect.a008334
M3 - Review article
C2 - 23284041
AN - SCOPUS:84872030260
VL - 5
JO - Cold Spring Harbor Perspectives in Biology
JF - Cold Spring Harbor Perspectives in Biology
SN - 1943-0264
IS - 1
ER -