Development of the brain's functional network architecture

Alecia C. Vogel, Jonathan D. Power, Steven E. Petersen, Bradley L. Schlaggar

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

A full understanding of the development of the brain's functional network architecture requires not only an understanding of developmental changes in neural processing in individual brain regions but also an understanding of changes in inter-regional interactions. Resting state functional connectivity MRI (rs-fcMRI) is increasingly being used to study functional interactions between brain regions in both adults and children. We briefly review methods used to study functional interactions and networks with rs-fcMRI and how these methods have been used to define developmental changes in network functional connectivity. The developmental rs-fcMRI studies to date have found two general properties. First, regional interactions change from being predominately anatomically local in children to interactions spanning longer cortical distances in young adults. Second, this developmental change in functional connectivity occurs, in general, via mechanisms of segregation of local regions and integration of distant regions into disparate subnetworks.

Original languageEnglish
Pages (from-to)362-375
Number of pages14
JournalNeuropsychology Review
Volume20
Issue number4
DOIs
StatePublished - Dec 2010

Keywords

  • Functional connectivity
  • Graph theory
  • Integration
  • Segregation
  • fMRI

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