Background: Oncolytic virotherapeutics is a promising platform for cancer treatment but the product class has yet been successful. The key to success is integration of bidirectional translational research to rapidly address issues encountered in the laboratory and the clinics. Objective: We highlight the hurdles identified for the targeted oncolytic virotherapy approach, specifically those identified in clinical trials with wild-type viruses and first-generation targeted agents. We also analyze the translational research and development that has been applied to overcome these hurdles, including virus engineering and design improvements for next-generation virotherapeutics. Results/conclusion: The iterative loop between the clinic and the lab can function as a major driving force to optimize products from this platform.

Original languageEnglish
Pages (from-to)1381-1391
Number of pages11
JournalExpert opinion on biological therapy
Issue number9
StatePublished - Sep 2008


  • Cancer
  • Clinical trial
  • Oncolytic virus
  • Targeted
  • Translational research


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