Development of targeted oncolytic virotherapeutics through translational research

Ta Chiang Liu, Tae Ho Hwang, John C. Bell, David H. Kirn

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Background: Oncolytic virotherapeutics is a promising platform for cancer treatment but the product class has yet been successful. The key to success is integration of bidirectional translational research to rapidly address issues encountered in the laboratory and the clinics. Objective: We highlight the hurdles identified for the targeted oncolytic virotherapy approach, specifically those identified in clinical trials with wild-type viruses and first-generation targeted agents. We also analyze the translational research and development that has been applied to overcome these hurdles, including virus engineering and design improvements for next-generation virotherapeutics. Results/conclusion: The iterative loop between the clinic and the lab can function as a major driving force to optimize products from this platform.

Original languageEnglish
Pages (from-to)1381-1391
Number of pages11
JournalExpert opinion on biological therapy
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2008

Keywords

  • Cancer
  • Clinical trial
  • Oncolytic virus
  • Targeted
  • Translational research

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