TY - JOUR
T1 - Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I
AU - Grossman, William J.
AU - Kimata, Jason T.
AU - Wong, Fen Hwa
AU - Zutter, Mary
AU - Ley, Timothy J.
AU - Ratner, Lee
PY - 1995/2/14
Y1 - 1995/2/14
N2 - The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.
AB - The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.
UR - http://www.scopus.com/inward/record.url?scp=0028889114&partnerID=8YFLogxK
U2 - 10.1073/pnas.92.4.1057
DO - 10.1073/pnas.92.4.1057
M3 - Article
C2 - 7862633
AN - SCOPUS:0028889114
SN - 0027-8424
VL - 92
SP - 1057
EP - 1061
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 4
ER -