Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I

William J. Grossman, Jason T. Kimata, Fen Hwa Wong, Mary Zutter, Timothy J. Ley, Lee Ratner

Research output: Contribution to journalArticlepeer-review

326 Scopus citations

Abstract

The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.

Original languageEnglish
Pages (from-to)1057-1061
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume92
Issue number4
DOIs
StatePublished - Feb 14 1995

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