The ontogeny of Ig(+), theta(+) and 'null' (Ig-,theta-) lymphocytes in the mouse spleen was followed. An event was found at about 10 days after birth when the percentage of Ig(+) lymphocytes in the spleen begins to rise sharply, and the percentage of 'null' lymphocytes falls. The Ig(+) lymphocytes before and after this event were then evaluated by four criteria pertaining to B cells. Three of these, the presence of C3 receptors, 'capping' behavior, and the amount and/or disposition of surface Ig distinguished the Ig(+) lymphocytes before the event described from those present afterward. The fourth criterion, the presence of Fc receptors, did not distinguish between the early and mature forms of Ig(+) lymphocytes.
|Number of pages||6|
|Journal||Journal of Immunology|
|State||Published - Dec 1 1975|