TY - JOUR
T1 - Development of a vitreous substitute
T2 - Incorporating charges and fibrous structures in synthetic hydrogel materials
AU - Morozova, Svetlana
AU - Hamilton, Paul
AU - Ravi, Nathan
AU - Muthukumar, Murugappan
N1 - Funding Information:
Acknowledgment is made to the National Science Foundation (DMR-1504265) and AFOSR Grant N0. FA9550-14-1-0164. This work was also supported by the National Institute of Health Grant EY021620 and Core Grant P30EY02687 and Research to Prevent Blindness.
Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/6/28
Y1 - 2016/6/28
N2 - Synthetic hydrogel systems are promising long-term candidates for therapeutic use as vitreous substitutes. To improve the swelling and mechanical properties of existing synthetic substitutes for the natural vitreous, we incorporate charges and fibrous structures. Using dynamic light scattering, rheology, and swelling techniques we show in vitro that synthetic copolymers of methacrylic acid (MAA), methylacrylamide (MAm), and bismethacryloylcystamine (BMAC) cross-linked with gellan match the water content, transport properties, and dynamic response of the natural vitreous better than previously proposed synthetic substitutes.
AB - Synthetic hydrogel systems are promising long-term candidates for therapeutic use as vitreous substitutes. To improve the swelling and mechanical properties of existing synthetic substitutes for the natural vitreous, we incorporate charges and fibrous structures. Using dynamic light scattering, rheology, and swelling techniques we show in vitro that synthetic copolymers of methacrylic acid (MAA), methylacrylamide (MAm), and bismethacryloylcystamine (BMAC) cross-linked with gellan match the water content, transport properties, and dynamic response of the natural vitreous better than previously proposed synthetic substitutes.
UR - http://www.scopus.com/inward/record.url?scp=84976542502&partnerID=8YFLogxK
U2 - 10.1021/acs.macromol.6b00885
DO - 10.1021/acs.macromol.6b00885
M3 - Article
AN - SCOPUS:84976542502
SN - 0024-9297
VL - 49
SP - 4619
EP - 4626
JO - Macromolecules
JF - Macromolecules
IS - 12
ER -