Development of a radiolabeled irreversible peptide ligand for PET imaging of vascular endothelial growth factor

Keyphrases

• 1,4,7-triazacyclononane 14%
• 1,5-difluoro-2,4-dinitrobenzene 14%
• 1-Fluoro-2,4-dinitrobenzene 14%
• 4-dinitrobenzene 100%
• Affinity Peptide Tag 14%
• After Injection 42%
• Agent-based 14%
• Binding Peptide 28%
• Biodistribution Study 14%
• C-terminal Lysine 14%
• Chelates 14%
• Co-injection 14%
• Covalent Binding 42%
• Dinitrophenyl 57%
• Fluoro 100%
• HCT116 14%
• High Affinity 14%
• Imaging Agents 28%
• Imaging Studies 14%
• In Vitro Binding 14%
• In Vitro Properties 14%
• Irreversible Binding 14%
• Ligand Affinity 14%
• N-terminus 14%
• Non-covalent Binding 28%
• Peptide Analogs 14%
• Peptide Ligand 100%
• Peptide Probe 28%
• PET Imaging 100%
• PET Imaging Agent 14%
• Pharmacokinetic Properties 14%
• Polyethylene Glycol 14%
• Proof of Concept Study 14%
• Standardized Uptake Value 14%
• Tumor Site 14%
• Tumor Uptake 28%
• Tumor Xenograft 14%
• Vascular Endothelial Growth Factor 100%
• Xenograft 14%

Pharmacology, Toxicology and Pharmaceutical Science

• 1 Fluoro 2,4 Dinitrobenzene 5%
• 2,4-Dinitrophenol 22%
• Biodistribution 5%
• Chelate 5%
• Copper 64 100%
• Lysine 5%
• Macrogol 5%
• Neoplasm 22%
• Nitrobenzene Derivative 44%
• Peptide 100%
• Pharmacokinetics 5%
• Polyethylene Terephthalate 100%
• Protein Tag 5%
• Tracer 5%
• Vasculotropin 100%