Development of a new α-aminonitrile synthesis

Guo Hua Chu; Minghua Gu; Baudouin Gerard; Roland E. Dolle

doi:10.1081/SCC-200043270

Development of a new α-aminonitrile synthesis

Guo Hua Chu
, Minghua Gu
, Baudouin Gerard
, Roland E. Dolle

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.

Original language	English
Pages (from-to)	4583-4590
Number of pages	8
Journal	Synthetic Communications
Volume	34
Issue number	24
DOIs	https://doi.org/10.1081/SCC-200043270
State	Published - 2004

Keywords

N-Trimethylsilylimines
Strecker synthesis
α-Amino-arylacetonitriles
α-Aminonitriles

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10.1081/SCC-200043270

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title = "Development of a new α-aminonitrile synthesis",

abstract = "α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.",

keywords = "N-Trimethylsilylimines, Strecker synthesis, α-Amino-arylacetonitriles, α-Aminonitriles",

author = "Chu, \{Guo Hua\} and Minghua Gu and Baudouin Gerard and Dolle, \{Roland E.\}",

year = "2004",

doi = "10.1081/SCC-200043270",

language = "English",

volume = "34",

pages = "4583--4590",

journal = "Synthetic Communications",

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T1 - Development of a new α-aminonitrile synthesis

AU - Chu, Guo Hua

AU - Gu, Minghua

AU - Gerard, Baudouin

AU - Dolle, Roland E.

PY - 2004

Y1 - 2004

N2 - α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.

AB - α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.

KW - N-Trimethylsilylimines

KW - Strecker synthesis

KW - α-Amino-arylacetonitriles

KW - α-Aminonitriles

UR - https://www.scopus.com/pages/publications/11244261332

U2 - 10.1081/SCC-200043270

DO - 10.1081/SCC-200043270

M3 - Article

AN - SCOPUS:11244261332

SN - 0039-7911

VL - 34

SP - 4583

EP - 4590

JO - Synthetic Communications

JF - Synthetic Communications

IS - 24

ER -

Development of a new α-aminonitrile synthesis

Abstract

Keywords

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