Development of a new α-aminonitrile synthesis

Guo Hua Chu, Minghua Gu, Baudouin Gerard, Roland E. Dolle

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.

Original languageEnglish
Pages (from-to)4583-4590
Number of pages8
JournalSynthetic Communications
Issue number24
StatePublished - 2004


  • N-Trimethylsilylimines
  • Strecker synthesis
  • α-Amino-arylacetonitriles
  • α-Aminonitriles


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