Abstract
α-Aminonitriles are prepared upon reaction of aryl carboxaldehydes with LiHMDS and acetone cyanohydrin. This new method provides a general route to the synthesis of various substituted α-aminoarylacetonitriles in high yield and purity, and avoids the use of the highly toxic cyanide salts.
Original language | English |
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Pages (from-to) | 4583-4590 |
Number of pages | 8 |
Journal | Synthetic Communications |
Volume | 34 |
Issue number | 24 |
DOIs | |
State | Published - 2004 |
Keywords
- N-Trimethylsilylimines
- Strecker synthesis
- α-Amino-arylacetonitriles
- α-Aminonitriles