Development of a multiciliated cell

Moe R. Mahjoub, Rashmi Nanjundappa, Megan N. Harvey

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Multiciliated cells (MCC) are evolutionary conserved, highly specialized cell types that contain dozens to hundreds of motile cilia that they use to propel fluid directionally. To template these cilia, each MCC produces between 30 and 500 basal bodies via a process termed centriole amplification. Much progress has been made in recent years in understanding the pathways involved in MCC fate determination, differentiation, and ciliogenesis. Recent studies using mammalian cell culture systems, mice, Xenopus, and other model organisms have started to uncover the mechanisms involved in centriole and cilia biogenesis. Yet, how MCC progenitor cells regulate the precise number of centrioles and cilia during their differentiation remains largely unknown. In this review, we will examine recent findings that address this fundamental question.

Original languageEnglish
Article number102105
JournalCurrent Opinion in Cell Biology
Volume77
DOIs
StatePublished - Aug 2022

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