Development of a high resolution image guided microirradiator (microIGRT)

E. W. Izaguirre, B. L. Kassebaum, J. Birch, I. T. Su, S. M. Goddu, D. A. Low

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Small animal in vivo anatomical (microCT and microMRI) and functional (microSPECT and microPET) imaging has fostered the development of radiopharmaceuticals and fundamental cancer research. Similar advances in the fields of radiobiology, radiotherapy planning, radiosensitizers, and radiation therapy are anticipated if dedicated small animal micro-conformal irradiation instruments are developed. We are presenting the design of a small animal image guided microirradiator (microIGRT) based on a high resolution microCT for anatomical imaging and treatment planning and a submillimeter focal spot orthovoltage source for high resolution conformal microirradiation. Each of the subsystems, the microCT and the microirradiator (microRT), have separate gantries which are placed in a coaxial instrument architecture. The on board microCT subsystem is a cone beam imaging tomographic scanner designed using a micro focus x-ray source and a flat panel amorphous silicon detector. The microRT subsystem was designed using an orthovoltage 320kVp x-ray source. Each subsystem is sequentially operated and a motorized animal bed transfers the small animal from the microCT imaging subsystem to the microRT subsystem. Treatment planning is performed during the transfer of the small animal by using an in house developed treatment planning. In this article, we report the design of the system and simulations performed to test the performance of our design.

Original languageEnglish
Title of host publication2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
Pages2690-2693
Number of pages4
DOIs
StatePublished - Dec 1 2009
Event2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009 - Orlando, FL, United States
Duration: Oct 25 2009Oct 31 2009

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Conference

Conference2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009
CountryUnited States
CityOrlando, FL
Period10/25/0910/31/09

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    Izaguirre, E. W., Kassebaum, B. L., Birch, J., Su, I. T., Goddu, S. M., & Low, D. A. (2009). Development of a high resolution image guided microirradiator (microIGRT). In 2009 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2009 (pp. 2690-2693). [5401982] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2009.5401982