Development of a broad-spectrum antiviral with activity against Ebola virus

M. Javad Aman, Michael S. Kinch, Kelly Warfield, Travis Warren, Abdul Yunus, Sven Enterlein, Eric Stavale, Peifang Wang, Shaojing Chang, Qingsong Tang, Kevin Porter, Michael Goldblatt, Sina Bavari

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73 Scopus citations

Abstract

We report herein the identification of a small molecule therapeutic, FGI-106, which displays potent and broad-spectrum inhibition of lethal viral hemorrhagic fevers pathogens, including Ebola, Rift Valley and Dengue Fever viruses, in cell-based assays. Using mouse models of Ebola virus, we further demonstrate that FGI-106 can protect animals from an otherwise lethal infection when used either in a prophylactic or therapeutic setting. A single treatment, administered 1 day after infection, is sufficient to protect animals from lethal Ebola virus challenge. Cell-based assays also identified inhibitory activity against divergent virus families, which supports a hypothesis that FGI-106 interferes with a common pathway utilized by different viruses. These findings suggest FGI-106 may provide an opportunity for targeting viral diseases.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalAntiviral Research
Volume83
Issue number3
DOIs
StatePublished - Sep 1 2009

Keywords

  • Antiviral
  • Dengue Fever
  • Ebola virus

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    Aman, M. J., Kinch, M. S., Warfield, K., Warren, T., Yunus, A., Enterlein, S., Stavale, E., Wang, P., Chang, S., Tang, Q., Porter, K., Goldblatt, M., & Bavari, S. (2009). Development of a broad-spectrum antiviral with activity against Ebola virus. Antiviral Research, 83(3), 245-251. https://doi.org/10.1016/j.antiviral.2009.06.001