@inbook{0caffdda521d40bf9c5c9e4349d2bc8f,
title = "Development and function of tissue-resident memory B cells",
abstract = "Barrier tissues are the primary site of infection for pathogens likely to cause future pandemics. Tissue-resident lymphocytes can rapidly detect pathogens upon infection of barrier tissues and are critical in preventing viral spread. However, most vaccines fail to induce tissue-resident lymphocytes and are instead reliant on circulating antibodies to mediate protective immunity. Circulating antibody titers wane over time following vaccination leaving individuals susceptible to breakthrough infections by variant viral strains that evade antibody neutralization. Memory B cells were recently found to establish tissue residence following infection of barrier tissues. Here, we summarize emerging evidence for the importance of tissue-resident memory B cells in the establishment of protective immunity against viral and bacterial challenge. We also discuss the role of tissue-resident memory B cells in regulating the progression of non-infectious diseases. Finally, we examine new approaches to develop vaccines capable of eliciting barrier immunity.",
keywords = "B cell, Barrier tissue, Germinal center, Immunological memory, Memory B cell, Mucosal immunity, Tissue-resident, Vaccination",
author = "Changfeng Chen and Laidlaw, {Brian J.}",
note = "Funding Information: The Laidlaw laboratory is supported by NIAID grants DP2AI169978 and K22AI153015. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIAID or NIH. Figures were created with Biorender.com. The authors contributed equally to all aspects of the article. C.C. and B.J.L. declare no competing interests. Funding Information: The Laidlaw laboratory is supported by NIAID grants DP2AI169978 and K22AI153015. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the NIAID or NIH. Figures were created with Biorender.com . Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = jan,
doi = "10.1016/bs.ai.2022.08.001",
language = "English",
isbn = "9780323989459",
series = "Advances in Immunology",
publisher = "Academic Press Inc.",
pages = "1--38",
editor = "Alt, {Frederick W.} and Murphy, {Kenneth M.}",
booktitle = "Advances in Immunology",
}