TY - JOUR
T1 - Developing novel treatments for mood disorders
T2 - Accelerating discovery
AU - Tamminga, Carol A.
AU - Nemeroff, Charles B.
AU - Blakely, Randy D.
AU - Brady, Linda
AU - Carter, Cameron S.
AU - Davis, Kenneth L.
AU - Dingledine, Raymond
AU - Gorman, Jack M.
AU - Grigoriadis, Dimitri E.
AU - Henderson, David C.
AU - Innis, Robert B.
AU - Killen, John
AU - Laughren, Thomas P.
AU - McDonald, William M.
AU - Murphy, Greer M.
AU - Paul, Steven M.
AU - Rudorfer, Matthew V.
AU - Sausville, Edward
AU - Schatzberg, Alan F.
AU - Scolnick, Edward M.
AU - Suppes, Trisha
PY - 2002/9/15
Y1 - 2002/9/15
N2 - This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad strokes, current pharmacologic treatments, and new directions in the field. Thereafter the topics focus on specific research initiatives that could advance the current therapeutics for mood disorders including new basic and clinical research in vivo human imaging procedures, somatic therapeutics, and the vast new area of pharmacogenetics. New scientific and technical opportunities exist today based on advances in basic neuroscience, opportunities in clinical testing, industry interest in advancing central nervous system therapeutics, and on active consumer advocacy groups. The question of how to bring all of these positive forces together to accelerate discovery in mood disorder therapeutics is the topic of this article.
AB - This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad strokes, current pharmacologic treatments, and new directions in the field. Thereafter the topics focus on specific research initiatives that could advance the current therapeutics for mood disorders including new basic and clinical research in vivo human imaging procedures, somatic therapeutics, and the vast new area of pharmacogenetics. New scientific and technical opportunities exist today based on advances in basic neuroscience, opportunities in clinical testing, industry interest in advancing central nervous system therapeutics, and on active consumer advocacy groups. The question of how to bring all of these positive forces together to accelerate discovery in mood disorder therapeutics is the topic of this article.
KW - Depression bipolar disorder research resources
KW - Government/industry collaboration
UR - http://www.scopus.com/inward/record.url?scp=0037106951&partnerID=8YFLogxK
U2 - 10.1016/S0006-3223(02)01470-1
DO - 10.1016/S0006-3223(02)01470-1
M3 - Review article
C2 - 12361670
AN - SCOPUS:0037106951
SN - 0006-3223
VL - 52
SP - 589
EP - 609
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 6
ER -