Developing novel treatments for mood disorders: Accelerating discovery

Carol A. Tamminga, Charles B. Nemeroff, Randy D. Blakely, Linda Brady, Cameron S. Carter, Kenneth L. Davis, Raymond Dingledine, Jack M. Gorman, Dimitri E. Grigoriadis, David C. Henderson, Robert B. Innis, John Killen, Thomas P. Laughren, William M. McDonald, Greer M. Murphy, Steven M. Paul, Matthew V. Rudorfer, Edward Sausville, Alan F. Schatzberg, Edward M. ScolnickTrisha Suppes

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations


This review was generated from discussions by the Pharmacologic and Somatic Treatments Section of the National Institute of Mental Health Strategic Plan for Mood Disorders Committee on advancing novel pharmacologic and somatic treatments for mood disorders. The opening section of the article summarizes in broad strokes, current pharmacologic treatments, and new directions in the field. Thereafter the topics focus on specific research initiatives that could advance the current therapeutics for mood disorders including new basic and clinical research in vivo human imaging procedures, somatic therapeutics, and the vast new area of pharmacogenetics. New scientific and technical opportunities exist today based on advances in basic neuroscience, opportunities in clinical testing, industry interest in advancing central nervous system therapeutics, and on active consumer advocacy groups. The question of how to bring all of these positive forces together to accelerate discovery in mood disorder therapeutics is the topic of this article.

Original languageEnglish
Pages (from-to)589-609
Number of pages21
JournalBiological Psychiatry
Issue number6
StatePublished - Sep 15 2002


  • Depression bipolar disorder research resources
  • Government/industry collaboration


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