Developing Microelectrode Arrays for the Point-of-Care Multiplex Detection of Metabolites

Yu Chia Chang, Benoit Arnould, Jennifer M. Heemstra, Kevin Moeller

Research output: Contribution to journalArticlepeer-review

Abstract

DNA-aptamer-functionalized electrode arrays can provide an intriguing method for detecting pathogen-derived exometabolites. This work addresses the limitations of previous aptamer-based pathogen detection methods by introducing a novel surface design that bridges the gap between initial efforts in this area and the demands of a point-of-care device. Specifically, the use of a diblock copolymer coating on a high-density microelectrode array and Cu-mediated cross coupling reactions that allow for the exclusive functionalization of that coating by any electrode or set of electrodes in the array provides a device that is stable for 1 year and compatible with the multiplex detection of small-molecule targets. The new chemistry developed allows one to take advantage of a large number of electrodes in the array with one experiment described herein capitalizing on the use of 960 individually addressable electrodes.

Original languageEnglish
Pages (from-to)14571-14580
Number of pages10
JournalAnalytical Chemistry
Volume96
Issue number36
DOIs
StatePublished - Sep 10 2024

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