TY - GEN
T1 - Developing a novel integrated model of p38 MAPK and glucocorticoid signalling pathways
AU - Holehouse, Alex
AU - Yang, Xian
AU - Adcock, Ian
AU - Guo, Yike
PY - 2012
Y1 - 2012
N2 - Glucocorticoid (GC) resistance is a key mechanism by which traditional asthma treatments become ineffective for patients, yet the molecular characteristics of the associated regulatory changes are largely unknown. Significant evidence suggests that crosstalk between p38 Mitogen Activated Protein Kinase (MAPK) and GC signalling pathways may contribute to this resistance. Based on a number of studies, a simplified GC signalling pathway model was developed and integrated with a pre-existing model of the p38 MAPK pathway. It is predicted that with experimental data, the validity and use of this model can be confirmed, corrections and updates can be made where necessary, and that through the two pathways' interface points the existence and scale of crosstalk can be examined.
AB - Glucocorticoid (GC) resistance is a key mechanism by which traditional asthma treatments become ineffective for patients, yet the molecular characteristics of the associated regulatory changes are largely unknown. Significant evidence suggests that crosstalk between p38 Mitogen Activated Protein Kinase (MAPK) and GC signalling pathways may contribute to this resistance. Based on a number of studies, a simplified GC signalling pathway model was developed and integrated with a pre-existing model of the p38 MAPK pathway. It is predicted that with experimental data, the validity and use of this model can be confirmed, corrections and updates can be made where necessary, and that through the two pathways' interface points the existence and scale of crosstalk can be examined.
UR - https://www.scopus.com/pages/publications/84864046849
U2 - 10.1109/CIBCB.2012.6217213
DO - 10.1109/CIBCB.2012.6217213
M3 - Conference contribution
AN - SCOPUS:84864046849
SN - 9781467311892
T3 - 2012 IEEE Symposium on Computational Intelligence and Computational Biology, CIBCB 2012
SP - 69
EP - 76
BT - 2012 IEEE Symposium on Computational Intelligence and Computational Biology, CIBCB 2012
T2 - 2012 IEEE Symposium on Computational Intelligence and Computational Biology, CIBCB 2012
Y2 - 9 May 2012 through 12 May 2012
ER -