Developing a biomarker for Neuropathic Arthropathy in diabetic patients

Fred Prior, Paul K. Commean, Tao Ju, Mary Hastings, Charles Hildebolt, David R. Sinacore

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

4 Scopus citations

Abstract

Neuropathic (Charcot's) Arthropathy (NCA) is a complication of diabetes mellitus which, in a high percentage of patients, leads to foot fracture, joint destruction, severe foot deformity, ulceration, instability, and possibly amputation. The development of new treatments is currently limited by the lack of biomarkers that are sensitive and specific indicators of NCA disease onset and treatment outcomes. There is evidence that those with NCA have low foot bone mineral densities (BMDs) and that foot BMDs further decrease during off-loading treatment. We have initiated a repeated measures cohort study in which clinical and radiological data are being collected with the objective to establish volumetric quantitative computed tomography (VQCT)-derived foot BMD as a candidate biomarker for acute. This paper presents the study design, methods and preliminary results.

Original languageEnglish
Title of host publication2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
PublisherIEEE Computer Society
Pages13-16
Number of pages4
ISBN (Print)9781424418138
DOIs
StatePublished - Jan 1 2007
Event2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA - Bethesda, MD, United States
Duration: Nov 8 2007Nov 9 2007

Publication series

Name2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA

Conference

Conference2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
CountryUnited States
CityBethesda, MD
Period11/8/0711/9/07

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