TY - GEN
T1 - Developing a biomarker for Neuropathic Arthropathy in diabetic patients
AU - Prior, Fred
AU - Commean, Paul K.
AU - Ju, Tao
AU - Hastings, Mary
AU - Hildebolt, Charles
AU - Sinacore, David R.
PY - 2007
Y1 - 2007
N2 - Neuropathic (Charcot's) Arthropathy (NCA) is a complication of diabetes mellitus which, in a high percentage of patients, leads to foot fracture, joint destruction, severe foot deformity, ulceration, instability, and possibly amputation. The development of new treatments is currently limited by the lack of biomarkers that are sensitive and specific indicators of NCA disease onset and treatment outcomes. There is evidence that those with NCA have low foot bone mineral densities (BMDs) and that foot BMDs further decrease during off-loading treatment. We have initiated a repeated measures cohort study in which clinical and radiological data are being collected with the objective to establish volumetric quantitative computed tomography (VQCT)-derived foot BMD as a candidate biomarker for acute. This paper presents the study design, methods and preliminary results.
AB - Neuropathic (Charcot's) Arthropathy (NCA) is a complication of diabetes mellitus which, in a high percentage of patients, leads to foot fracture, joint destruction, severe foot deformity, ulceration, instability, and possibly amputation. The development of new treatments is currently limited by the lack of biomarkers that are sensitive and specific indicators of NCA disease onset and treatment outcomes. There is evidence that those with NCA have low foot bone mineral densities (BMDs) and that foot BMDs further decrease during off-loading treatment. We have initiated a repeated measures cohort study in which clinical and radiological data are being collected with the objective to establish volumetric quantitative computed tomography (VQCT)-derived foot BMD as a candidate biomarker for acute. This paper presents the study design, methods and preliminary results.
UR - http://www.scopus.com/inward/record.url?scp=50849096391&partnerID=8YFLogxK
U2 - 10.1109/LSSA.2007.4400873
DO - 10.1109/LSSA.2007.4400873
M3 - Conference contribution
AN - SCOPUS:50849096391
SN - 9781424418138
T3 - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
SP - 13
EP - 16
BT - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
PB - IEEE Computer Society
T2 - 2007 IEEE/NIH Life Science Systems and Applications Workshop, LISA
Y2 - 8 November 2007 through 9 November 2007
ER -