TY - JOUR
T1 - Determining conserved metabolic biomarkers from a million database queries
AU - Kurczy, Michael E.
AU - Ivanisevic, Julijana
AU - Johnson, Caroline H.
AU - Uritboonthai, Winnie
AU - Hoang, Linh
AU - Fang, Mingliang
AU - Hicks, Matthew
AU - Aldebot, Anthony
AU - Rinehart, Duane
AU - Mellander, Lisa J.
AU - Tautenhahn, Ralf
AU - Patti, Gary J.
AU - Spilker, Mary E.
AU - Benton, H. Paul
AU - Siuzdak, Gary
N1 - Publisher Copyright:
© The Author 2015. Published by Oxford University Press. All rights reserved.
PY - 2015/6/18
Y1 - 2015/6/18
N2 - Motivation: Metabolite databases provide a unique window into metabolome research allowing the most commonly searched biomarkers to be catalogued. Omic scale metabolite profiling, or metabolomics, is finding increased utility in biomarker discovery largely driven by improvements in analytical technologies and the concurrent developments in bioinformatics. However, the successful translation of biomarkers into clinical or biologically relevant indicators is limited. Results: With the aim of improving the discovery of translatable metabolite biomarkers, we present search analytics for over one million METLIN metabolite database queries. The most common metabolites found in METLIN were cross-correlated against XCMS Online, the widely used cloud-based data processing and pathway analysis platform. Analysis of the METLIN and XCMS common metabolite data has two primary implications: these metabolites, might indicate a conserved metabolic response to stressors and, this data may be used to gauge the relative uniqueness of potential biomarkers.
AB - Motivation: Metabolite databases provide a unique window into metabolome research allowing the most commonly searched biomarkers to be catalogued. Omic scale metabolite profiling, or metabolomics, is finding increased utility in biomarker discovery largely driven by improvements in analytical technologies and the concurrent developments in bioinformatics. However, the successful translation of biomarkers into clinical or biologically relevant indicators is limited. Results: With the aim of improving the discovery of translatable metabolite biomarkers, we present search analytics for over one million METLIN metabolite database queries. The most common metabolites found in METLIN were cross-correlated against XCMS Online, the widely used cloud-based data processing and pathway analysis platform. Analysis of the METLIN and XCMS common metabolite data has two primary implications: these metabolites, might indicate a conserved metabolic response to stressors and, this data may be used to gauge the relative uniqueness of potential biomarkers.
UR - https://www.scopus.com/pages/publications/84950300127
U2 - 10.1093/bioinformatics/btv475
DO - 10.1093/bioinformatics/btv475
M3 - Article
C2 - 26275895
AN - SCOPUS:84950300127
SN - 1367-4803
VL - 31
SP - 3721
EP - 3724
JO - Bioinformatics
JF - Bioinformatics
IS - 23
ER -