Determination of the mechanical response of the chondrocyte in situ using finite element modeling and confocal microscopy

Farshid Guilak, Van C. Mow

Research output: Chapter in Book/Report/Conference proceedingConference contribution

31 Scopus citations

Abstract

Using finite element modeling, the spatial and temporal mechanical response of the extracellular matrix have been described under a variety of mechanical loading configurations. In other studies, a linear biphasic finite element model has been used to describe the mechanical response of the tissue including structurally distinct inclusions such as chondrocytes. In this manner, the effects of various morphological characteristics, such as cell shape or intercellular spacing, can be parametrically examined. Using confocal microscopy, three-dimensional changes in cell shape and volume were measured during compression of the matrix. Using finite element optimization methods, the theoretical predictions of cell shape and experimental measurements from confocal microscopy can be combined in order to determine the intrinsic material properties of the chondrocyte.

Original languageEnglish
Title of host publication1992 Advances in Bioengineering
PublisherPubl by ASME
Pages21-23
Number of pages3
ISBN (Print)0791811166
StatePublished - Dec 1 1992
Externally publishedYes
EventWinter Annual Meeting of the American Society of Mechanical Engineers - Anaheim, CA, USA
Duration: Nov 8 1992Nov 13 1992

Publication series

NameAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Volume22

Conference

ConferenceWinter Annual Meeting of the American Society of Mechanical Engineers
CityAnaheim, CA, USA
Period11/8/9211/13/92

Fingerprint Dive into the research topics of 'Determination of the mechanical response of the chondrocyte in situ using finite element modeling and confocal microscopy'. Together they form a unique fingerprint.

  • Cite this

    Guilak, F., & Mow, V. C. (1992). Determination of the mechanical response of the chondrocyte in situ using finite element modeling and confocal microscopy. In 1992 Advances in Bioengineering (pp. 21-23). (American Society of Mechanical Engineers, Bioengineering Division (Publication) BED; Vol. 22). Publ by ASME.