Determination of molar activity of [18F]fluoride by HPLC via sulfonyl derivatization

Dong Zhou; Sally Schwarz; John A. Katzenellenbogen

doi:10.1016/j.apradiso.2021.109865

Determination of molar activity of [¹⁸F]fluoride by HPLC via sulfonyl derivatization

Dong Zhou
, Sally Schwarz
, John A. Katzenellenbogen

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The molar activity of [¹⁸F]fluoride was determined by HPLC of sulfonyl fluorides, which have high UV absorbance and are formed exclusively from sulfonyl chlorides and [¹⁸F]fluoride in aqueous solution. The measurable limit of sulfonyl fluorides is as low as 0.1 ppm, allowing measurements up to the theoretical molar activity of [¹⁸F]fluoride. The method was validated with standard solutions of fluoride, and provides a convenient way to measure molar activity of [¹⁸F]fluoride using only HPLC without specialized equipment.

Original language	English
Article number	109865
Journal	Applied Radiation and Isotopes
Volume	176
DOIs	https://doi.org/10.1016/j.apradiso.2021.109865
State	Published - Oct 2021

Keywords

Fluorine-18
HPLC
Molar activity
Sulfonyl fluoride

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10.1016/j.apradiso.2021.109865

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title = "Determination of molar activity of [18F]fluoride by HPLC via sulfonyl derivatization",

abstract = "The molar activity of [18F]fluoride was determined by HPLC of sulfonyl fluorides, which have high UV absorbance and are formed exclusively from sulfonyl chlorides and [18F]fluoride in aqueous solution. The measurable limit of sulfonyl fluorides is as low as 0.1 ppm, allowing measurements up to the theoretical molar activity of [18F]fluoride. The method was validated with standard solutions of fluoride, and provides a convenient way to measure molar activity of [18F]fluoride using only HPLC without specialized equipment.",

keywords = "Fluorine-18, HPLC, Molar activity, Sulfonyl fluoride",

author = "Dong Zhou and Sally Schwarz and Katzenellenbogen, \{John A.\}",

note = "Funding Information: This work was supported by the National Institutes of Health (NIH: CA25836 to J.A.K.). The authors thank the Cyclotron Facility in Medicine School, Washington University in Saint Louis for 18 F production. Funding Information: This work was supported by the National Institutes of Health (NIH: CA25836 to J.A.K.). The authors thank the Cyclotron Facility in Medicine School, Washington University in Saint Louis for 18F production. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = oct,

doi = "10.1016/j.apradiso.2021.109865",

language = "English",

volume = "176",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

}

TY - JOUR

T1 - Determination of molar activity of [18F]fluoride by HPLC via sulfonyl derivatization

AU - Zhou, Dong

AU - Schwarz, Sally

AU - Katzenellenbogen, John A.

N1 - Funding Information: This work was supported by the National Institutes of Health (NIH: CA25836 to J.A.K.). The authors thank the Cyclotron Facility in Medicine School, Washington University in Saint Louis for 18 F production. Funding Information: This work was supported by the National Institutes of Health (NIH: CA25836 to J.A.K.). The authors thank the Cyclotron Facility in Medicine School, Washington University in Saint Louis for 18F production. Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/10

Y1 - 2021/10

N2 - The molar activity of [18F]fluoride was determined by HPLC of sulfonyl fluorides, which have high UV absorbance and are formed exclusively from sulfonyl chlorides and [18F]fluoride in aqueous solution. The measurable limit of sulfonyl fluorides is as low as 0.1 ppm, allowing measurements up to the theoretical molar activity of [18F]fluoride. The method was validated with standard solutions of fluoride, and provides a convenient way to measure molar activity of [18F]fluoride using only HPLC without specialized equipment.

AB - The molar activity of [18F]fluoride was determined by HPLC of sulfonyl fluorides, which have high UV absorbance and are formed exclusively from sulfonyl chlorides and [18F]fluoride in aqueous solution. The measurable limit of sulfonyl fluorides is as low as 0.1 ppm, allowing measurements up to the theoretical molar activity of [18F]fluoride. The method was validated with standard solutions of fluoride, and provides a convenient way to measure molar activity of [18F]fluoride using only HPLC without specialized equipment.

KW - Fluorine-18

KW - HPLC

KW - Molar activity

KW - Sulfonyl fluoride

UR - https://www.scopus.com/pages/publications/85110737695

U2 - 10.1016/j.apradiso.2021.109865

DO - 10.1016/j.apradiso.2021.109865

M3 - Article

C2 - 34274781

AN - SCOPUS:85110737695

SN - 0969-8043

VL - 176

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 109865

ER -

Determination of molar activity of [¹⁸F]fluoride by HPLC via sulfonyl derivatization

Abstract

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