Determination of molar activity of [18F]fluoride by HPLC via sulfonyl derivatization

Dong Zhou, Sally Schwarz, John A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review


The molar activity of [18F]fluoride was determined by HPLC of sulfonyl fluorides, which have high UV absorbance and are formed exclusively from sulfonyl chlorides and [18F]fluoride in aqueous solution. The measurable limit of sulfonyl fluorides is as low as 0.1 ppm, allowing measurements up to the theoretical molar activity of [18F]fluoride. The method was validated with standard solutions of fluoride, and provides a convenient way to measure molar activity of [18F]fluoride using only HPLC without specialized equipment.

Original languageEnglish
Article number109865
JournalApplied Radiation and Isotopes
StatePublished - Oct 2021


  • Fluorine-18
  • HPLC
  • Molar activity
  • Sulfonyl fluoride


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