@article{e0a95b4a931b43cda9a01584f7cb9de0,
title = "Determination of molar activity of [18F]fluoride by HPLC via sulfonyl derivatization",
abstract = "The molar activity of [18F]fluoride was determined by HPLC of sulfonyl fluorides, which have high UV absorbance and are formed exclusively from sulfonyl chlorides and [18F]fluoride in aqueous solution. The measurable limit of sulfonyl fluorides is as low as 0.1 ppm, allowing measurements up to the theoretical molar activity of [18F]fluoride. The method was validated with standard solutions of fluoride, and provides a convenient way to measure molar activity of [18F]fluoride using only HPLC without specialized equipment.",
keywords = "Fluorine-18, HPLC, Molar activity, Sulfonyl fluoride",
author = "Dong Zhou and Sally Schwarz and Katzenellenbogen, {John A.}",
note = "Funding Information: This work was supported by the National Institutes of Health (NIH: CA25836 to J.A.K.). The authors thank the Cyclotron Facility in Medicine School, Washington University in Saint Louis for 18 F production. Funding Information: This work was supported by the National Institutes of Health (NIH: CA25836 to J.A.K.). The authors thank the Cyclotron Facility in Medicine School, Washington University in Saint Louis for 18F production. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = oct,
doi = "10.1016/j.apradiso.2021.109865",
language = "English",
volume = "176",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
}