Determination of antigenic peptide selection by heterozygote APC containing I-A g7 - I-A X

Ilan Vidavsky, James J. Walters, Michael L. Gross, Anish Suri, Osami Kanagawa, Emil R. Unanue

Research output: Contribution to conferencePaper

Abstract

The determination of peptide extract taken from l-A g7 cell line was discussed. The peptides were extracted from l-A g7 and other structurally similar MHC (l-A g7pd and l-A d) and peptide repertoire of homozygotic cell lines were compared to that of heterozygotic cell lines. A large number of peptides were analyzed using tendem MS. 25 peptide sequences were determined using MASCOT as the database search program, by using reverse phase-nano-LC and the LCQ-deca. The results show that most of the peptides selected by l-A g7 are unusually rich in acidic residues toward their C-termini.

Original languageEnglish
Pages31-32
Number of pages2
StatePublished - Dec 1 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Conference

ConferenceProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period06/2/0206/6/02

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    Vidavsky, I., Walters, J. J., Gross, M. L., Suri, A., Kanagawa, O., & Unanue, E. R. (2002). Determination of antigenic peptide selection by heterozygote APC containing I-A g7 - I-A X . 31-32. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.