Determinants of plasma uric acid

C. L. Gulbrandsen; N. E. Morton; D. C. Rao; G. G. Rhoads; A. Kagan

doi:10.1007/BF00399397

Determinants of plasma uric acid

C. L. Gulbrandsen
, N. E. Morton
, D. C. Rao
, G. G. Rhoads
, A. Kagan

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.

Original language	English
Pages (from-to)	307-312
Number of pages	6
Journal	Human genetics
Volume	50
Issue number	3
DOIs	https://doi.org/10.1007/BF00399397
State	Published - Sep 1979

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title = "Determinants of plasma uric acid",

abstract = "Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.",

author = "Gulbrandsen, \{C. L.\} and Morton, \{N. E.\} and Rao, \{D. C.\} and Rhoads, \{G. G.\} and A. Kagan",

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AU - Gulbrandsen, C. L.

AU - Morton, N. E.

AU - Rao, D. C.

AU - Rhoads, G. G.

AU - Kagan, A.

PY - 1979/9

Y1 - 1979/9

N2 - Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.

AB - Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.

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SN - 0340-6717

VL - 50

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JO - Human genetics

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Determinants of plasma uric acid

Abstract

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