Determinants of plasma uric acid

C. L. Gulbrandsen, N. E. Morton, D. C. Rao, G. G. Rhoads, A. Kagan

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.

Original languageEnglish
Pages (from-to)307-312
Number of pages6
JournalHuman genetics
Volume50
Issue number3
DOIs
StatePublished - Sep 1979

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