Determinants and outcomes of acute pancreatitis in patients hospitalized for COVID-19: Early pandemic experience

Mohammad Aldiabat, Yassine Kilani, Iqra Arshad, Tabeer Rana, Wesam Aleyadeh, Omar Al Ta'ani, Yazan Aljabiri, Saqr Alsakarneh, Thaer Abdelfattah, Laith Alhuneafat, Amar Manvar

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To examine the predictors and outcomes associated with the development of acute pancreatitis (AP) in patients hospitalized with Coronavirus Disease 2019 (COVID-19). Methods: This is an observational analysis of the 2020 National Inpatient Sample Database. The study includes adult patients who were admitted with a confirmed diagnosis of COVID-19 and stratifies them based on the presence or absence of AP during their hospitalization. Predictors of AP development between the two groups and differences in outcomes are examined. Multivariate logistic regression analysis using Stata/BE 17.0 is conducted, with adjustments made for age, sex, race, and Charlson Comorbidity Index (CCI). Statistical significance is determined at a p-value of <0.05. Results: Significant factors associated with an increased risk of AP in COVID-19 patients include Hispanic ethnicity, higher Charlson Comorbidity Index (CCI) score, residence in states located in the southern region, history of chronic kidney disease, chronic liver disease, malnutrition, portal hypertension, and alcohol use. COVID-19 patients who developed AP were also found to be at higher risk of adverse outcomes, including mortality, acute coronary syndrome, acute kidney injury, sepsis, septic shock, in-hospital cardiac arrest, invasive mechanical ventilation, upper gastrointestinal bleeding, prolonged length of stay, and increased healthcare cost. Conclusions: In hospitalized patients with COVID-19, the presence of AP is associated with increased mortality and morbidity. Risk factors for developing AP in this population include Hispanic ethnicity, residence in the southern region, higher Charlson Comorbidity Index (CCI) score, history of chronic kidney disease, chronic liver disease, malnutrition, portal hypertension, and alcohol use.

Original languageEnglish
Pages (from-to)926-934
Number of pages9
JournalPancreatology
Volume23
Issue number8
DOIs
StatePublished - Dec 2023

Keywords

  • Acute pancreatitis
  • Complications
  • Epidemiology
  • Outcomes
  • Predictors
  • SARS-CoV-2

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