Infusion of low concentrations of angiotensin into the isolated perfused rat kidney greatly enhances the increase in renal resistance produced by renal nerve stimulation. The augmentation of adrenergic stimulation induced by angiotensin is inhibited by the specific antagonist [8 cysteine] angiotensin II. Inhibition of renal prostaglandin biosynthesis by indomethacin augments the renal vasoconstriction produced by nerve stimulation. Thus, endogenous prostaglandin appears to play a role in the regulation of renal resistance.
|Number of pages||5|
|Journal||American Journal of Physiology|
|State||Published - Dec 1 1974|