Determinants and modification of adrenergic and vascular resistance in the kidney

P. Needleman, G. R. Marshall, E. M. Johnson

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Infusion of low concentrations of angiotensin into the isolated perfused rat kidney greatly enhances the increase in renal resistance produced by renal nerve stimulation. The augmentation of adrenergic stimulation induced by angiotensin is inhibited by the specific antagonist [8 cysteine] angiotensin II. Inhibition of renal prostaglandin biosynthesis by indomethacin augments the renal vasoconstriction produced by nerve stimulation. Thus, endogenous prostaglandin appears to play a role in the regulation of renal resistance.

Original languageEnglish
Pages (from-to)665-669
Number of pages5
JournalAmerican Journal of Physiology
Volume227
Issue number3
StatePublished - Dec 1 1974

Fingerprint Dive into the research topics of 'Determinants and modification of adrenergic and vascular resistance in the kidney'. Together they form a unique fingerprint.

  • Cite this