Detection of synchronous primary malignancies with 68Ga-labeled prostate-specific membrane antigen PET/CT in patients with prostate cancer: Frequency in 764 patients

Medhat M. Osman, Amir Iravani, Rodney J. Hicks, Michael S. Hofman

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We evaluated the incidence of synchronous primary malignancies in patients undergoing 68Ga-labeled prostate-specific membrane antigen PET/CT for prostate cancer (PC). Methods: Reports for 764 PC patients were reviewed. Incidental lesions atypical for PC metastases and suggestive of a synchronous primary malignancy were identified. Follow-up was obtained to confirm etiology. Results: Lesions atypical for PC metastases were found in 49 (6.4%) of 764 patients, and a synchronous primary malignancy was confirmed in 5 patients (0.7%; 2 lung, 1 lymphoma, 1 thyroid, and 1 base of tongue). In 8 patients (1.0%), lesions were proven to be atypical metastases from PC. In 24 patients (3.1%), lesions had a benign etiology. Follow-up was not available in 12 patients (1.6%). Conclusion: Synchronous 68Ga-labeled prostate-specific membrane antigen-avid malignancies were rare (0.7%) in PC patients; atypical lesions were more commonly unusual PC metastases (1.0%) or benign (3.1%).

Original languageEnglish
Pages (from-to)1938-1942
Number of pages5
JournalJournal of Nuclear Medicine
Volume58
Issue number12
DOIs
StatePublished - Dec 1 2017

Keywords

  • Ga-PSMA
  • PET/CT
  • Prostate cancer
  • Synchronous primary malignancy

Fingerprint

Dive into the research topics of 'Detection of synchronous primary malignancies with 68Ga-labeled prostate-specific membrane antigen PET/CT in patients with prostate cancer: Frequency in 764 patients'. Together they form a unique fingerprint.

Cite this