Detection of novel sequences related to African swine fever virus in human serum and sewage

Joy Loh, Guoyan Zhao, Rachel M. Presti, Lori R. Holtz, Stacy R. Finkbeiner, Lindsay Droit, Zoilmar Villasana, Collin Todd, James M. Pipas, Byron Calgua, Rosina Girones, David Wang, Herbert W. Virgin

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.

Original languageEnglish
Pages (from-to)13019-13025
Number of pages7
JournalJournal of virology
Volume83
Issue number24
DOIs
StatePublished - Dec 2009

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