Detection of novel sequences related to African swine fever virus in human serum and sewage

Joy Loh; Guoyan Zhao; Rachel M. Presti; Lori R. Holtz; Stacy R. Finkbeiner; Lindsay Droit; Zoilmar Villasana; Collin Todd; James M. Pipas; Byron Calgua; Rosina Girones; David Wang; Herbert W. Virgin

doi:10.1128/JVI.00638-09

Detection of novel sequences related to African swine fever virus in human serum and sewage

Joy Loh, Guoyan Zhao, Rachel M. Presti, Lori R. Holtz, Stacy R. Finkbeiner, Lindsay Droit, Zoilmar Villasana, Collin Todd, James M. Pipas, Byron Calgua, Rosina Girones, David Wang, Herbert W. Virgin

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.

Original language	English
Pages (from-to)	13019-13025
Number of pages	7
Journal	Journal of virology
Volume	83
Issue number	24
DOIs	https://doi.org/10.1128/JVI.00638-09
State	Published - Dec 2009

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title = "Detection of novel sequences related to African swine fever virus in human serum and sewage",

abstract = "The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.",

author = "Joy Loh and Guoyan Zhao and Presti, {Rachel M.} and Holtz, {Lori R.} and Finkbeiner, {Stacy R.} and Lindsay Droit and Zoilmar Villasana and Collin Todd and Pipas, {James M.} and Byron Calgua and Rosina Girones and David Wang and Virgin, {Herbert W.}",

year = "2009",

month = dec,

doi = "10.1128/JVI.00638-09",

language = "English",

volume = "83",

pages = "13019--13025",

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T1 - Detection of novel sequences related to African swine fever virus in human serum and sewage

AU - Loh, Joy

AU - Zhao, Guoyan

AU - Presti, Rachel M.

AU - Holtz, Lori R.

AU - Finkbeiner, Stacy R.

AU - Droit, Lindsay

AU - Villasana, Zoilmar

AU - Todd, Collin

AU - Pipas, James M.

AU - Calgua, Byron

AU - Girones, Rosina

AU - Wang, David

AU - Virgin, Herbert W.

PY - 2009/12

Y1 - 2009/12

N2 - The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.

AB - The family Asfarviridae contains only a single virus species, African swine fever virus (ASFV). ASFV is a viral agent with significant economic impact due to its devastating effects on populations of domesticated pigs during outbreaks but has not been reported to infect humans. We report here the discovery of novel viral sequences in human serum and sewage which are clearly related to the asfarvirus family but highly divergent from ASFV. Detection of these sequences suggests that greater genetic diversity may exist among asfarviruses than previously thought and raises the possibility that human infection by asfarviruses may occur.

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DO - 10.1128/JVI.00638-09

M3 - Article

C2 - 19812170

AN - SCOPUS:72849125120

SN - 0022-538X

VL - 83

SP - 13019

EP - 13025

JO - Journal of virology

JF - Journal of virology

IS - 24

ER -

Detection of novel sequences related to African swine fever virus in human serum and sewage

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