@article{ccbaf98e9c334d94b21da2444abb0acb,
title = "Detection of deletions in the mitochondrial genome of Caenorhabditis elegans",
abstract = "We have examined an aging population of Caenorhabditis elegans via a PCR assay to determine if deletions in the mitochondrial genome occur in the nematode. We detected eight such deletions, identified the breakpoints of four of these, and discovered direct repeats of 4-8 base pairs at the site of all four deletions. Six of the eight repeats involved in the deletions are located in or immediately adjacent to tRNAs. Without a biochemical bias, the probability of direct repeats being present at all four breakpoints was 4×10-6.",
author = "Simon Melov and Hertz, {Gerald Z.} and Stormo, {Gary D.} and Johnson, {Thomas E.}",
note = "Funding Information: We would like to thank Barbara Bowers and Jeanne Wehner for computing assistance. We also wish to thank Anatoly Ulyanov and Eric E.Snyder for helpful comments on this manuscript. S.Melov and T.E.Johnson are supported by Grants from the National Institutes of Health AG10248 and AG83202 and G.Z.Hertz and G.D.Stormo are supported by HGO0249. We would also like to thank the reviewers for constructive comments regarding the tRNAs.",
year = "1994",
month = mar,
day = "25",
doi = "10.1093/nar/22.6.1075",
language = "English",
volume = "22",
pages = "1075--1078",
journal = "Nucleic acids research",
issn = "0305-1048",
number = "6",
}