Detection of cortical lesions in multiple sclerosis: A new imaging approach

Kevin R. Patel; Jie Luo; Enrique Alvarez; Laura Piccio; Robert E. Schmidt; Dmitriy A. Yablonskiy; Anne H. Cross

doi:10.1177/2055217315606465

Detection of cortical lesions in multiple sclerosis: A new imaging approach

Kevin R. Patel, Jie Luo, Enrique Alvarez, Laura Piccio, Robert E. Schmidt, Dmitriy A. Yablonskiy, Anne H. Cross

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Cortical lesions occur early in multiple sclerosis (MS) and are thought to have clinical implications. Conventional MRI is insensitive to cortical pathology. Investigational imaging modalities show improved but incomplete cortical lesion detection and are time and resource intensive. Gradient echo plural contrast imaging (GEPCI) is sensitive to MS white matter pathology and can be performed on standard MRI scanners. Here we used GEPCI to examine autopsied MS frontal brain tissues. Two cortical MS lesions were visually distinguished from surrounding tissue by GEPCI and immunohistochemical staining. Furthermore, these lesions were quantitatively differentiated from healthy tissue using GEPCI-derived metrics.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Multiple Sclerosis Journal - Experimental, Translational and Clinical
Volume	1
DOIs	https://doi.org/10.1177/2055217315606465
State	Published - Sep 15 2015

Keywords

Multiple sclerosis
brain imaging
cerebral cortex
diagnostic
gray matter
imaging
magnetic resonance imaging

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title = "Detection of cortical lesions in multiple sclerosis: A new imaging approach",

abstract = "Cortical lesions occur early in multiple sclerosis (MS) and are thought to have clinical implications. Conventional MRI is insensitive to cortical pathology. Investigational imaging modalities show improved but incomplete cortical lesion detection and are time and resource intensive. Gradient echo plural contrast imaging (GEPCI) is sensitive to MS white matter pathology and can be performed on standard MRI scanners. Here we used GEPCI to examine autopsied MS frontal brain tissues. Two cortical MS lesions were visually distinguished from surrounding tissue by GEPCI and immunohistochemical staining. Furthermore, these lesions were quantitatively differentiated from healthy tissue using GEPCI-derived metrics.",

keywords = "Multiple sclerosis, brain imaging, cerebral cortex, diagnostic, gray matter, imaging, magnetic resonance imaging",

author = "Patel, {Kevin R.} and Jie Luo and Enrique Alvarez and Laura Piccio and Schmidt, {Robert E.} and Yablonskiy, {Dmitriy A.} and Cross, {Anne H.}",

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T2 - A new imaging approach

AU - Patel, Kevin R.

AU - Luo, Jie

AU - Alvarez, Enrique

AU - Piccio, Laura

AU - Schmidt, Robert E.

AU - Yablonskiy, Dmitriy A.

AU - Cross, Anne H.

PY - 2015/9/15

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N2 - Cortical lesions occur early in multiple sclerosis (MS) and are thought to have clinical implications. Conventional MRI is insensitive to cortical pathology. Investigational imaging modalities show improved but incomplete cortical lesion detection and are time and resource intensive. Gradient echo plural contrast imaging (GEPCI) is sensitive to MS white matter pathology and can be performed on standard MRI scanners. Here we used GEPCI to examine autopsied MS frontal brain tissues. Two cortical MS lesions were visually distinguished from surrounding tissue by GEPCI and immunohistochemical staining. Furthermore, these lesions were quantitatively differentiated from healthy tissue using GEPCI-derived metrics.

AB - Cortical lesions occur early in multiple sclerosis (MS) and are thought to have clinical implications. Conventional MRI is insensitive to cortical pathology. Investigational imaging modalities show improved but incomplete cortical lesion detection and are time and resource intensive. Gradient echo plural contrast imaging (GEPCI) is sensitive to MS white matter pathology and can be performed on standard MRI scanners. Here we used GEPCI to examine autopsied MS frontal brain tissues. Two cortical MS lesions were visually distinguished from surrounding tissue by GEPCI and immunohistochemical staining. Furthermore, these lesions were quantitatively differentiated from healthy tissue using GEPCI-derived metrics.

KW - Multiple sclerosis

KW - brain imaging

KW - cerebral cortex

KW - diagnostic

KW - gray matter

KW - imaging

KW - magnetic resonance imaging

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JO - Multiple Sclerosis Journal - Experimental, Translational and Clinical

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ER -

Detection of cortical lesions in multiple sclerosis: A new imaging approach

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