Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging

Randy L. Buckner, Peter A. Bandettini, Kathleen M. O'Craven, Robert L. Savoy, Steven E. Petersen, Marcus E. Raichle, Bruce R. Rosen

Research output: Contribution to journalArticle

473 Scopus citations

Abstract

Functional neuroimaging studies in human subjects using positron emission tomography or functional magnetic resonance imaging (fMRI) are typically conducted by collecting data over extended time periods that contain many similar trials of a task. Here methods for acquiring fMRI data from single trials of a cognitive task are reported. In experiment one, whole brain fMRI was used to reliably detect single-trial responses in a prefrontal region within single subjects. In experiment two, higher temporal sampling of a more limited spatial field was used to measure temporal offsets between regions. Activation maps produced solely from the single-trial data were comparable to those produced from blocked runs. These findings suggest that single-trial paradigms will be able to exploit the high temporal resolution of fMRI. Such paradigms will provide experimental flexibility and time- resolved data for individual brain regions on a trial-by-trial basis.

Original languageEnglish
Pages (from-to)14878-14883
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number25
DOIs
StatePublished - Dec 10 1996

Keywords

  • language
  • neuroimaging
  • prefrontal
  • single trial

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