Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)

Whitney R. Grither; Brendan C. Dickson; Katherine C. Fuh; Ian S. Hagemann

doi:10.1016/j.gore.2020.100636

Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)

Whitney R. Grither, Brendan C. Dickson, Katherine C. Fuh, Ian S. Hagemann

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses.

Original language	English
Article number	100636
Journal	Gynecologic Oncology Reports
Volume	34
DOIs	https://doi.org/10.1016/j.gore.2020.100636
State	Published - Nov 2020

Keywords

Fusion gene
Pathology
RNA-sequencing
Uterine tumor resembling ovarian sex cord tumor
Uterine tumors

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title = "Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)",

abstract = "Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses.",

keywords = "Fusion gene, Pathology, RNA-sequencing, Uterine tumor resembling ovarian sex cord tumor, Uterine tumors",

author = "Grither, {Whitney R.} and Dickson, {Brendan C.} and Fuh, {Katherine C.} and Hagemann, {Ian S.}",

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year = "2020",

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T1 - Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)

AU - Grither, Whitney R.

AU - Dickson, Brendan C.

AU - Fuh, Katherine C.

AU - Hagemann, Ian S.

PY - 2020/11

Y1 - 2020/11

N2 - Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses.

AB - Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare uterine neoplasm of uncertain malignant potential. We present the case of a 69-year-old woman who underwent hysterectomy for postmenopausal bleeding and was found to have a myometrial UTROSCT. RNA-sequencing identified a somatic GREB1–NCOA1 fusion, supporting the diagnosis. Next-generation sequencing is increasingly being adopted in diagnostic pathology laboratories. This report highlights the value of RNA-sequencing in identifying rare fusion events to support pathologic diagnoses.

KW - Fusion gene

KW - Pathology

KW - RNA-sequencing

KW - Uterine tumor resembling ovarian sex cord tumor

KW - Uterine tumors

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AN - SCOPUS:85090939248

SN - 2352-5789

VL - 34

JO - Gynecologic Oncology Reports

JF - Gynecologic Oncology Reports

M1 - 100636

ER -

Detection of a somatic GREB1-NCOA1 gene fusion in a uterine tumor resembling ovarian sex cord tumor (UTROSCT)

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Keywords

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