Detecting vascular biosignatures with a colloidal, radio-opaque polymeric nanoparticle

Dipanjan Pan, Todd A. Williams, Angana Senpan, John S. Allen, Mike J. Scott, Patrick J. Gaffney, Samuel A. Wickline, Gregory M. Lanza

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.

Original languageEnglish
Pages (from-to)15522-15527
Number of pages6
JournalJournal of the American Chemical Society
Issue number42
StatePublished - Oct 28 2009


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