Detecting epistatic interactions contributing to quantitative traits

Robert Culverhouse, Tsvika Klein, William Shannon

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


The restricted partition method (RPM) is a partitioning algorithm for examining multi-locus genotypes as (potentially non-additive) predictors of a quantitative trait. The motivating application was to develop a robust method to examine quantitative phenotypes for epistasis (gene-gene interactions), but the method can be applied without modification to gene-environment interactions. Simulation results indicate that the method provides an efficient way to identify loci contributing epistatically to a quantitative trait, even if the loci have no single locus effects. Statistical significance can be estimated through permutation testing. An example using real data involving the metabolism of a chemotherapy drug is included for illustration. Although the examples in this article involve 2-locus interactions, the RPM is computationally feasible for the analysis of more than two loci or factors.

Original languageEnglish
Pages (from-to)141-152
Number of pages12
JournalGenetic Epidemiology
Issue number2
StatePublished - Sep 2004


  • Methodology
  • Pharmacogenetics
  • Statistics


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