Desmoplastic melanoma: A pathologically and clinically distinct form of cutaneous melanoma

William G. Hawkins, Klaus J. Busam, Leah Ben-Porat, Katherine S. Panageas, Daniel G. Coit, David E. Gyorki, David C. Linehan, Mary S. Brady

Research output: Contribution to journalArticlepeer-review

121 Scopus citations

Abstract

Background: Desmoplastic melanoma (DM) is a rare variant characterized by the presence of fusiform melanocytes in a sclerotic stroma. Pathologic heterogeneity within DM may account for the controversy regarding the clinical presentation and prognosis of DM compared with conventional melanoma (CM). Methods: We identified 131 patients with a diagnosis of DM seen between 1979 and 2002. Tumors were categorized as either pure DM (pDM; n = 92), if desmoplasia was prominent throughout the entire invasive tumor, or mixed DM (mDM; n = 39), if fibrosis was well developed in only parts of an otherwise non-DM. Differences in clinical behavior among pDM, mDM, and CM (n = 3976) were examined. Results: Seventy-three percent of patients with DM had tumors >2 mm in depth, compared with 31% of patients with CM (P < .001). Regional nodal metastasis was uncommon in patients who presented with clinically localized pDM (1%) compared with those with mDM (10%) or CM (6%) (P < .05, pDM vs. CM). Five-year melanoma-specific mortality was lower for patients who presented with pDM compared with mDM (11% vs. 31%; P < .01). Patients with pDM and CM had a similar melanoma-specific mortality despite a 3-fold difference in median tumor depth (3.6 vs. 1.2 mm, respectively). Conclusions: DMs can be divided into two subtypes based on a histological quantification of desmoplasia. Tumors with prominent fibrosis (pure subtype) are unlikely to disseminate to regional lymph nodes and are associated with a favorable outcome when compared with those with mixed desmoplasia or CM.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalAnnals of Surgical Oncology
Volume12
Issue number3
DOIs
StatePublished - Mar 2005

Keywords

  • Desmoplastic melanoma
  • Lymph node
  • Recurrence
  • Survival

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