Designing vaccines to neutralize effective toxin delivery by enterotoxigenic Escherichia coli

James M. Fleckenstein, Alaullah Sheikh

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Enterotoxigenic Escherichia coli (ETEC) are a leading cause of diarrheal illness in developing countries. Despite the discovery of these pathogens as a cause of cholera-like diarrhea over 40 years ago, and decades of vaccine development effort, there remains no broadly protective ETEC vaccine. The discovery of new virulence proteins and an improved appreciation of the complexity of the molecular events required for effective toxin delivery may provide additional avenues to pursue in development of an effective vaccine to prevent severe diarrhea caused by these important pathogens.

Original languageEnglish
Pages (from-to)1799-1812
Number of pages14
JournalToxins
Volume6
Issue number6
DOIs
StatePublished - Jun 2014

Keywords

  • Diarrhea
  • Enterotoxigenic Escherichia coli
  • Enterotoxin
  • Heat-labile enterotoxin
  • Heat-stable enterotoxin
  • Live-attenuated
  • Neutralizing antibodies
  • Subunit
  • Vaccines

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